Overview This review article discusses the therapeutic potential of gene editing, focusing on mRNA-based delivery systems. It highlights the advancements in gene editing technologies like CRISPR-Cas systems and base editors, and examines their applications in treating...
“Everything in the last 14 years of genome editing has been based on CRISPR. We have been whipping this horse for a decade and a half, but we need more programmable functions with complexity beyond the molecular scissors that cut RNA and DNA,” says Patrick Hsu, PhD,...
A recent study published in Nature Biomedical Engineering presents a new method for more efficient and precise integration of large genes into mammalian genomes. The research, led by Smriti Pandey, Xin D. Gao, and their team, introduces prime-editing-assisted...
Introduction The advent of CRISPR technology has revolutionized genome editing, offering unprecedented precision and versatility. Central to this innovation are the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas)...
Introduction:The quest for precision in CRISPR-Cas9 gene editing takes a significant leap forward with the development of BreakTag, a method devised to enhance our understanding of DNA double-strand breaks (DSBs) induced by Cas9. This breakthrough, detailed in a...
