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Custom mRNA Service

Accelerating your vaccine and drug development from discovery to production

mRNA Services

  • mRNA (messenger RNA) is a promising substrate for novel therapeutics and has emerged as a leading candidate for vaccines, and therapies for cancers or genetic disorders. mRNA holds several unique properties that are advantageous in the development of new therapies, including highly localized expression patterns, rapid development time, and a high degree of safety as a non-genome editing substrate for therapies.

    PackGene provides custom mRNA production with superior quality, industry-leading timelines, a wide range of deliverables, and stringent quality control. Our mRNA services can help to streamline the vaccine and drug development process and accelerate the translation of scientific discoveries into practical therapies by helping to smooth the transition from early research and development to GMP mRNA manufacturing.

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Key Benefits

  • Superior Quality

    High mRNA integrity with a comprehensive QC panel

  • Customizable Solutions

    Flexible scales, enhanced stability, tailored modifications

  • End-to-End Support

    Expert guidance and scalable manufacturing

Service Details

Catalog Capping and modification Gene Quantity Timeline(Business days)
mRNA Custom mRNA Cap1 Custom gene 100μg-20mg 10-15
Custom mRNA Cap1 N1meΨU

*Additional time (~2-3 weeks ) for custom gene synthesis

 

mRNA grade and QC standard

QC Category QC Item Method Specification Research Grade Add-on
Identification Appearance Visual Inspection Clear and free of foreign particles √
mRNA Concentration UV Absorbance by Nanodrop ≥1mg/ml √
RNA Integrity/size Capillary Electrophoresis Target ±30%, Expected band size detected √
Buffer Specification Client Spec RnaseFree H2O(default), PBS, 1mM Sodium Citrate, pH 6.4 √
Purity A 260/280 Ratio UV Absorbance by Nanodrop 1.70-2.30 √
Size based purity Capillary Electrophoresis >80% √
Impurity Total Protein residue Nano Orange ≤1% √
Plamsid DNA residue qPCR ≤0.1% √
dsRNA Slot-blot ≤1% √
Safety Endotoxin Semiquantitative LAL <10EU/mg √
Endotoxin Quantitative <10EU/mg √
Bioburden Direct Inoculation No growth after 48 hrs √
Raw material-Linearization Linearization percentage AGE >95% √ HPLC
Host cell DNA Quantitative PCR ≤ 5% √
Total protein Nano Orange ≤1% √
RNA AGE Non-detectable by gel electrophoresis at 200ng √
Raw material -circular Plasmid Gene of Interest Sanger sequencing 100% math reference sequence (not including poly A) √
Poly A Sanger sequencing ≤110A ±5nt, ≤111-125A ±8nt √
Poly A Length Enzyme digestion and CE Target ±5% √

Performance

  • mRNA Integrity

    mRNA Integrity1

     

    mRNA Integrity2

  • mRNA Expression

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