Our capsid library services focus on screening novel AAV serotypes to optimize tissue specificity and serotype tropism. Using cutting-edge techniques like DNA shuffling, we generate diverse AAV serotypes that offer distinct advantages in gene therapy applications. This enables us to:
- Enhance the specificity and efficiency of gene delivery
- Minimize the risk of off-target effects
- Bypass innate immune responses
Our Gene of Interest (GOI) library services involve promoter engineering to optimize gene expression and improve promoter tissue specificity. This ensures that your therapeutic genes are expressed at the right levels in the desired tissues, providing:
- Optimized gene expression
- Improved promoter tissue specificity
We provide comprehensive Gene editing library services for gene function screening, gene knockdown studies, disease modeling, cancer research, and drug target discovery. Our libraries include custom CRISPR sgRNA libraries, CRISPR activation libraries, CRISPRi libraries, CRISPR knockout libraries and shRNA libraries, enabling high-throughput screening to identify critical genes and pathways involved in various diseases and uncover potential therapeutic targets., facilitating:
- Gene function screening
- Disease modeling
- Drug target discovery
- Cancer research
Success in Serotype Screening
Random peptide Library
Up to 20 amino acids each site with the random peptide insertion Combinatorial mutation throughout the peptide insertion.
Precision Library
A short precision oligo pool that encodes gRNA library or other predesigned sequence insert into the vector. Each variant sequence can be predefined and precisely synthesized
DNA shuffling Library
Pre-synthesized gene library ligate together to create a combinatorial gene shuffling library.
~100 Capsid Genes ready to use
Your variant will be labeled with a barcode that adjacent or distant from the variable region. The barcode will enable easy variant identification by NGS or track cell lineage.
More library design we can handle
Site-Saturation Library
Up to 20 amino acids at single sites
1 amino acid change per variant
Saturation Scanning Library
Up to 20 amino acids at a series of sites you choose
1 amino acid change per variant
Combinatorial Mutant Library
You define the amino acid or nucleotide components and position; we generate the library from the template. Multiple mutation per variant in a combinatorial way
Library performance
AAV Vector Design & Construction
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AAV Packaging Services
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Plasmid Preparation
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