AAV Packaging Services

PackGene delivers industry-leading AAV packaging services to support your gene therapy projects. Our proprietary production platform, featuring optimized cell lines and enhanced RC and helper plasmids, maximizes virus yield. With years of expertise, we have perfected protocols to produce over 70 AAV serotypes with high titer, purity, potency, and consistency.

As a result, our growing base of satisfied customers repeatedly relies on us for their AAV vector cloning and packaging needs. Beyond Research, NHP, and HT-grade AAV for your pre-clinical studies, we also offer GMP-grade AAV manufacturing for clinical applications.

Key Benefits

PackGene AAV Packaging Service
	Research Grade	NHP Grade	HT Grade
Application	Cell culture, small animal	Small animal or non-human primates	Cell culture
Scale	2E+12 ~ 8E+14 GC	1E+13 ~ 1E+16	2E+11 ~ 2E+13 GC
Lead time	Start from 12 business days	Start from 17 business days	7-14 business days
QC test	qPCR, SDS-PAGE Coomassie Blue Staining, endotoxin LAL, plasmid restriction enzyme digestion	ddPCR, SDS-PAGE Silver Staining, endotoxin LAL, plasmid restriction enzyme digestion	qPCR
Performance Comparison
Titration	qPCR, Titer meet requirements	ddPCR, Titer meet requirements	qPCR, Titer meet requirements
AAV purity analysis	SDS-PAGE, Coomassie Blue Staining, Capsid band size meet reference	SDS-PAGE, Silver Staining, Capsid band size meet reference, Capsid band size meet reference	-
Endotoxin Test	LAL, <10EU/mL	LAL, <1EU/ml (endotoxin removal may reach <0.2EU/ml)	-
Mycoplasma	-	qPCR, Negative	-
Bioburden	-	48 hr, no growth	-
AAV Genome integrity	-	Capillary Electrophoresis, report value	-
Empty Capsid	TEM, guaranteed empty capsid rate <30% for common serotypes	TEM, guaranteed empty capsid rate <20% for common serotypes	-
TEM images