Webinar: Current Challenges and New Approaches to Developing rAAV Manufacturing Processes for Large-scale GMP Production

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Abstract

Adeno-associated virus (AAV) production faces significant challenges, including low yields, scalability issues, and inconsistent quality. Scaling up AAV production to meet clinical and commercial demands requires innovative solutions. PackGene’s proprietary π-Alpha 293 AAV High-yield Platform addresses these challenges by utilizing a uniquely designed RC plasmid within a triple-plasmid transfection system. This approach boosts AAV production by 3 to 8 times across various serotypes. Additionally, the platform integrates in-process upstream and downstream Quality by Design (QbD) optimizations, enhancing total AAV yield up to 10-fold. A single batch of production can deliver high-yield vector genomes, sufficient for most clinical and commercial AAV applications.

Time

7/02/2024 2:00 pm EST/ 11:00am PST

Speaker:

  • Berenice-Carrillo

    Name: Dr. Berenice Carrillo

    Company: PackGene Biotech USA

    Title: Associate Director of Process and Analytical Development

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  • Ran-Li

    Name: Dr. Ran Li

    Company: PackGene Biotech USA

    Title: Associate Director of Process and Analytical

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