
Webinar: Current Challenges and New Approaches to Developing rAAV Manufacturing Processes for Large-scale GMP Production
Abstract
Adeno-associated virus (AAV) production faces significant challenges, including low yields, scalability issues, and inconsistent quality. Scaling up AAV production to meet clinical and commercial demands requires innovative solutions. PackGene’s proprietary π-Alpha 293 AAV High-yield Platform addresses these challenges by utilizing a uniquely designed RC plasmid within a triple-plasmid transfection system. This approach boosts AAV production by 3 to 8 times across various serotypes. Additionally, the platform integrates in-process upstream and downstream Quality by Design (QbD) optimizations, enhancing total AAV yield up to 10-fold. A single batch of production can deliver high-yield vector genomes, sufficient for most clinical and commercial AAV applications.
Time
7/02/2024 2:00 pm EST/ 11:00am PST
Speaker:
-
Name: Dr. Berenice Carrillo
Company: PackGene Biotech USA
Title: Associate Director of Process and Analytical Development
-
Name: Dr. Ran Li
Company: PackGene Biotech USA
Title: Associate Director of Process and Analytical