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Cap 1 N1meψ EPO mRNA
EPO mRNA encodes the human erythropoietin (EPO) protein, which regulates erythropoiesis (red blood cell production) and contributes to wound healing and the brain’s response to neural injury. Kariko et al. demonstrated that transfecting EPO mRNA in vivo led to substantial increases in reticulocyte counts and hematocrits. This mRNA possesses a Cap1 structure, which is highly efficient in capping. It is fully substituted with N1-methyl-pseudo Uridine to improve expression and decrease immunogenicity. Additionally, the mRNA features a 110A tail in its sequence, resembling a mature mRNA.
SKU: RNAP031
title
content
Gene name
EPO
Function
Reporter
ORF sequence
ATGGGGGTGCACGAATGTCCTGCCTGGCTGTGGCTTCTCCTGTCCCTGCTGTCGCTCCCTCTGGGCCTCCCAGTCCTGGGCGCCCCACCACGCCTCATCTGTGACAGCCGAGTCCTGGAGAGGTACCTCTTGGAGGCCAAGGAGGCCGAGAATATCACGACGGGCTGTGCTGAACACTGCAGCTTGAATGAGAATATCACTGTCCCAGACACCAAAGTTAATTTCTATGCCTGGAAGAGGATGGAGGTCGGGCAGCAGGCCGTAGAAGTCTGGCAGGGCCTGGCCCTGCTGTCGGAAGCTGTCCTGCGGGGCCAGGCCCTGTTGGTCAACTCTTCCCAGCCGTGGGAGCCCCTGCAGCTGCATGTGGATAAAGCCGTCAGTGGCCTTCGCAGCCTCACCACTCTGCTTCGGGCTCTGGGAGCCCAGAAGGAAGCCATCTCCCCTCCAGATGCGGCCTCAGCTGCTCCACTCCGAACAATCACTGCTGACACTTTCCGCAAACTCTTCCGAGTCTACTCCAATTTCCTCCGGGGAAAGCTGAAGCTGTACACAGGGGAGGCCTGCAGGACAGGGGACAGATGA
Species
Homo sapiens
Cellular localization of the protein
Cytosol
Reference/PubMed link
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31934-7
Concentration
1mg/mL
Storage Buffer
Rnase Free H2O
Gene length (bp)
582
Molecular Weight (kDa)
337.7
Storage Temperature
-80°C
Shipping Condition
Dry ice
Appearance
Clear and colorless
Purity
Fragment analysis by capillary electrophoresis
Base Composition
N1meψ
Capping
Cap1
Tag
N-HA
Stock
On-demand