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Decibel, Principal Scientist
“A lot of our programs internally have been having great results with the AAV vectors you all have been packaging. PackGene is rapidly becoming our go-to for AAV vectors! ”
Biogen Scientist
“I have spreaded the word of my satisfaction with your AAV vectors to many people in Biogen’s research labs and I hope we continue to be a regular customer in the future.”
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PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F
BioRxiv. 2023 Nov 13 Maryna V. Ivanchenko, Daniel M. Hathaway, Eric M. Mulhall, Kevin T. Booth, Mantian Wang, Cole W. Peters, Alex J. Klein, Xinlan Chen, Yaqiao Li, Bence György and David P. Corey Products used in the paper Details Operation AAV vector AAVs were...
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Nature Biomedical Engineering. 2023 Dec 6 Christiano R. R. Alves, Leillani L. Ha, Rebecca Yaworski, Emma R. Sutton, Cicera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly, Ariane Beauvais, Roman M. Doll, Demitri de la Cruz, Casey A. Maguire, Kathryn J. Swoboda,...
Intranasal mask for protecting the respiratory tract against viral aerosols
Nature Communications. 2023 Dec 18 Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang,...
NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue
Research Square. 2023 Dec 14 Liang Xu, Qingsong Wang, Jiancheng Liao, Jiajun Zheng, Bing Qin, Wen Li, Jiaxuan Zhang, Wei Li, Xiangyu Wang, Maoying Zhang, Gong Chen Products used in the paper Details Operation AAV vector packaging Adeno-associated virus (AAV): AAV9...
Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
Neuron. 2023 Dec 20 Ngan Pan Bennett Au, Tan Wu, Xinyu Chen, Feng Gao, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H. Geschwind, Giovanni Coppola, Xin Wang, and Chi Him Eddie Ma Products used in the paper Details Operation AAV vector packaging...
The Study on PLA-based nano-bio effects and its biomedical applications
. 2023 Aug DING Zhaowen Products used in the paper Details Operation was used as a negative control Request Quote Research Field: Coronavirus Keywords: PLA, nano-bio interfacial interaction, lamella nanomaterial, microsphere AAV Serotype: pseudovirus Animal or cell...
Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle
Genes. 2024 Feb 21 Danyang Fan, Yilong Yao, Yanwen Liu, Chao Yan, Fanqinyu Li, Shilong Wang, Mei Yu, Bingkun Xie and Zhonglin Tang Products used in the paper Details Operation AAV vector packaging AAV1-hOTOF was developed by researchers at the Eye & ENT Hospital of...
Enhancing transduction efficiency of adeno-associated virus 9 by cell line engineering: implication for gene therapy potency assay
Biotechnology and Bioprocess Engineering. 2024 Feb 19 Nanyeong Go, Changhyun Ahn & Jae Young Lee Products used in the paper Details Operation AAV vector packaging In brief, mice were intranasally infected with AAV-hACE2 (PackGene Biotech, Guangzhou, China) Request...
Advanced Therapies Congress (Philly, PA, Nov 12-13)
Make your mark at the Advanced Therapies Congress in Philadelphia this November, where global leaders in gene and cell therapy, regenerative medicine, and related fields gather for top-tier education, scientific exchange, and networking. Exhibit your product or...
SITC (Houston, TX, Nov 6-10)
Join us at SITC's 39th Annual Meeting, the premier cancer immunotherapy conference, where global leaders from academia, industry, and government come together for cutting-edge education, scientific exchange, and networking. Showcase your product or service to advance...
ESGCT 2024 (Rome, Italy, Oct 22-25)
The ESGCT supports scientists and clinicians in gene and cell therapy, promoting research, collaboration, and awareness. With new delivery vectors and genome engineering advancements, more life-changing treatments are possible. Join us at the Annual Congress in Rome...
Advancing Gene and Cell Therapies for Cancer (Philly, PA, Oct 16-17)
Join ASGCT at the Wyndham Philadelphia Historic District, Oct. 16-17, 2024, for an unparalleled opportunity to immerse yourself in the latest research related to gene and cell therapy for cancer in Philadelphia's vibrant Historic District.Time: Oct 16-17, 2024Address:...
Webinar: Current Challenges and New Approaches to Developing rAAV Manufacturing Processes for Large-scale GMP Production
Abstract:Adeno-associated virus (AAV) production faces significant challenges, including low yields, scalability issues, and inconsistent quality. Scaling up AAV production to meet clinical and commercial demands requires innovative solutions. PackGene's proprietary...
Cell & Gene Meeting on the MESA (ARM; Phoenix, AZ, Oct 7-9)
The 2024 Cell & Gene Meeting on the Mesa is the premier annual conference for industry leaders, focused on innovative research and overcoming commercial challenges in cell and gene therapy. The event features expert panels, networking opportunities, and over 100...
Socienty for Neuroscience (Chicago, IL, Oct 5-9)
Annually, scientists from across the globe gather to explore new concepts, present their research, and experience the pinnacle of their field. By attending, you can present your own research, network with fellow scientists, participate in sessions and events, and...
CASSS-CGTP ( Rockville, MD, Jun 11-13)
The Cell and Gene Therapy Products (CGTP) Symposium focuses on Manufacturing, Quality, and Regulatory Considerations, fostering an exchange of scientific ideas and interactions with regulators that shape evolving regulatory frameworks for these innovative products....
Preclinical Studies Highlight Novel Gene Therapy for IgA Nephropathy Treatment
San Diego, CA – October 28, 2024 At the recent ASN Kidney Week 2024 (October 23–27), researchers presented promising preclinical data on PS-002, an innovative gene therapy aimed at treating IgA nephropathy (IgAN), an autoimmune kidney disease. The therapy, developed...
[2024/10/25] Gene and Cell Therapy- weekly digest from PackGene
FeaturedNewsArticlesPackGene's NewsletterReceive the latest news and insights to your inbox.About PackGenePackGene Biotech is a world-leading CRO and CDMO, excelling in AAV vectors, mRNA, plasmid DNA, and lentiviral vector solutions. Our comprehensive offerings span...
Lipin1 Inhibition Enhances Axon Regeneration: A Potential Therapeutic Approach for Spinal Cord Injury
Traumatic injuries to the central nervous system (CNS) often result in permanent functional deficits due to the limited capacity of CNS neurons to regenerate. Although advancements in spinal cord injury (SCI) research have been made, achieving substantial nerve fiber...
CRISPR therapy reduces swelling attacks by 81% in Intellia follow-up study
The promise of a one-and-done CRISPR infusion is beginning to look more real than ever. On Thursday, Intellia Therapeutics announced that an experimental gene editing therapy reduced dangerous and unpredictable swelling attacks caused by the disease hereditary...
Sangamo Therapeutics Secures Accelerated Approval Pathway for Gene Therapy in Fabry Disease
Sangamo Therapeutics has announced a major advancement in its gene therapy program for Fabry disease, as the U.S. FDA has provided a clear pathway for Accelerated Approval. This decision could potentially speed up approval timelines by three years, with a Biologics...
Orna Therapeutics Unveils Novel In Vivo Gene Editing Data Highlighting Engineering and Delivery Approach at the 31st Annual European Society of Gene & Cell Therapy Congress
--Lead type V editor program in SCD demonstrates industry leading delivery and repeat dosing with a passive LNP-- --Results reveal unprecedented improvement of editing rates from single digits to nearly 80% in primary HSPCs-- Orna Therapeutics, a biotechnology company...
Affinia Therapeutics to Highlight New Data on Genetic Cardiomyopathy Programs and BBB-Penetrant Capsids Leveraging Novel Receptors at the European Society of Gene & Cell Therapy 2024 31st Annual Congress
AFTX-201, Affinia's gene therapy program in BAG3 dilated cardiomyopathy, demonstrates efficacy, safety, and differentiation in a genetically relevant preclinical model, with full restoration of cardiac function Additional data show Affinia's gene therapy program in...
Nanoscope Publishes Breakthrough Showing MCO-010 Treatment Arrests Neurodegeneration
Nanoscope Therapeutics Inc., a late-stage clinical biotechnology company developing gene therapies for retinal degenerative diseases today announced a breakthrough discovery in Translational Vision Science & Technology (TVST, an ARVO journal) demonstrating that...
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