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Decibel, Principal Scientist
“A lot of our programs internally have been having great results with the AAV vectors you all have been packaging. PackGene is rapidly becoming our go-to for AAV vectors! ”
Biogen Scientist
“I have spreaded the word of my satisfaction with your AAV vectors to many people in Biogen’s research labs and I hope we continue to be a regular customer in the future.”
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PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F
BioRxiv. 2023 Nov 13 Maryna V. Ivanchenko, Daniel M. Hathaway, Eric M. Mulhall, Kevin T. Booth, Mantian Wang, Cole W. Peters, Alex J. Klein, Xinlan Chen, Yaqiao Li, Bence György and David P. Corey Products used in the paper Details Operation AAV vector AAVs were...
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Nature Biomedical Engineering. 2023 Dec 6 Christiano R. R. Alves, Leillani L. Ha, Rebecca Yaworski, Emma R. Sutton, Cicera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly, Ariane Beauvais, Roman M. Doll, Demitri de la Cruz, Casey A. Maguire, Kathryn J. Swoboda,...
Intranasal mask for protecting the respiratory tract against viral aerosols
Nature Communications. 2023 Dec 18 Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang,...
NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue
Research Square. 2023 Dec 14 Liang Xu, Qingsong Wang, Jiancheng Liao, Jiajun Zheng, Bing Qin, Wen Li, Jiaxuan Zhang, Wei Li, Xiangyu Wang, Maoying Zhang, Gong Chen Products used in the paper Details Operation AAV vector packaging Adeno-associated virus (AAV): AAV9...
Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
Neuron. 2023 Dec 20 Ngan Pan Bennett Au, Tan Wu, Xinyu Chen, Feng Gao, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H. Geschwind, Giovanni Coppola, Xin Wang, and Chi Him Eddie Ma Products used in the paper Details Operation AAV vector packaging...
The Study on PLA-based nano-bio effects and its biomedical applications
. 2023 Aug DING Zhaowen Products used in the paper Details Operation was used as a negative control Request Quote Research Field: Coronavirus Keywords: PLA, nano-bio interfacial interaction, lamella nanomaterial, microsphere AAV Serotype: pseudovirus Animal or cell...
Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle
Genes. 2024 Feb 21 Danyang Fan, Yilong Yao, Yanwen Liu, Chao Yan, Fanqinyu Li, Shilong Wang, Mei Yu, Bingkun Xie and Zhonglin Tang Products used in the paper Details Operation AAV vector packaging AAV1-hOTOF was developed by researchers at the Eye & ENT Hospital of...
Enhancing transduction efficiency of adeno-associated virus 9 by cell line engineering: implication for gene therapy potency assay
Biotechnology and Bioprocess Engineering. 2024 Feb 19 Nanyeong Go, Changhyun Ahn & Jae Young Lee Products used in the paper Details Operation AAV vector packaging In brief, mice were intranasally infected with AAV-hACE2 (PackGene Biotech, Guangzhou, China) Request...
Advanced Therapies Congress (Philly, PA, Nov 12-13)
Make your mark at the Advanced Therapies Congress in Philadelphia this November, where global leaders in gene and cell therapy, regenerative medicine, and related fields gather for top-tier education, scientific exchange, and networking. Exhibit your product or...
SITC (Houston, TX, Nov 6-10)
Join us at SITC's 39th Annual Meeting, the premier cancer immunotherapy conference, where global leaders from academia, industry, and government come together for cutting-edge education, scientific exchange, and networking. Showcase your product or service to advance...
ESGCT 2024 (Rome, Italy, Oct 22-25)
The ESGCT supports scientists and clinicians in gene and cell therapy, promoting research, collaboration, and awareness. With new delivery vectors and genome engineering advancements, more life-changing treatments are possible. Join us at the Annual Congress in Rome...
Advancing Gene and Cell Therapies for Cancer (Philly, PA, Oct 16-17)
Join ASGCT at the Wyndham Philadelphia Historic District, Oct. 16-17, 2024, for an unparalleled opportunity to immerse yourself in the latest research related to gene and cell therapy for cancer in Philadelphia's vibrant Historic District.Time: Oct 16-17, 2024Address:...
Webinar: Current Challenges and New Approaches to Developing rAAV Manufacturing Processes for Large-scale GMP Production
Abstract:Adeno-associated virus (AAV) production faces significant challenges, including low yields, scalability issues, and inconsistent quality. Scaling up AAV production to meet clinical and commercial demands requires innovative solutions. PackGene's proprietary...
Cell & Gene Meeting on the MESA (ARM; Phoenix, AZ, Oct 7-9)
The 2024 Cell & Gene Meeting on the Mesa is the premier annual conference for industry leaders, focused on innovative research and overcoming commercial challenges in cell and gene therapy. The event features expert panels, networking opportunities, and over 100...
Socienty for Neuroscience (Chicago, IL, Oct 5-9)
Annually, scientists from across the globe gather to explore new concepts, present their research, and experience the pinnacle of their field. By attending, you can present your own research, network with fellow scientists, participate in sessions and events, and...
CASSS-CGTP ( Rockville, MD, Jun 11-13)
The Cell and Gene Therapy Products (CGTP) Symposium focuses on Manufacturing, Quality, and Regulatory Considerations, fostering an exchange of scientific ideas and interactions with regulators that shape evolving regulatory frameworks for these innovative products....
MeiraGTx’s AAV Gene Therapy Shows Promising Results for Parkinson’s
MeiraGTx has reported encouraging results from a midphase trial of its investigational gene therapy, AAV-GAD, for treating Parkinson’s disease. The company is now in discussions with regulators to advance the program to Phase III clinical trials.Significant...
[2024/10/11] Gene and Cell Therapy- weekly digest from PackGene
FeaturedNewsArticlesPackGene's NewsletterReceive the latest news and insights to your inbox.About PackGenePackGene Biotech is a world-leading CRO and CDMO, excelling in AAV vectors, mRNA, plasmid DNA, and lentiviral vector solutions. Our comprehensive offerings span...
Ultragenyx Provides Update on Stage 1 Cohorts in Phase 1/2/3 Cyprus2+ Study for Wilson Disease with AAV9 Gene Therapy
October 3, 2024 NOVATO, Calif. — Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE) has announced promising results from the ongoing Phase 1/2/3 Cyprus2+ study evaluating UX701 gene therapy for Wilson disease. Early-stage data from Stage 1 of the trial revealed significant...
World-First CAR-T Therapy Using Donor Cells Sends Autoimmune Diseases into Remission
In a groundbreaking advancement, three individuals suffering from severe autoimmune diseases have achieved remission after receiving a revolutionary therapy using donor-derived immune cells. This pioneering treatment, which utilized bioengineered immune cells known as...
Novel gene therapy shows promise in targeting a mutation linked to epilepsy
Clearance of mutant protein & restoration of normal neuronal activity by Gapmer ASO. Credit: NUS MedicineResearchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) are working on a therapy that holds potential in treating...
Purespring nabs $105M to take gene therapy into the clinic as IgAN field matures
Purespring Therapeutics has reeled in £80 million ($105 million) to test two gene therapies in humans. The Sofinnova Partners-led Series B, disclosed Wednesday morning, will carry the London startup into an open-label Phase 1/2 next year for a kidney disease that has...
A Philadelphia biotech designed a first-of-its-kind therapy for rare cancer: Now, it waits for patients
Credit: Pixabay/CC0 Public DomainWithin the next couple of weeks, the first blood samples from patients will arrive at the loading dock of Adaptimmune, a biotechnology company headquartered on the northeastern edge of the Navy Yard. Their arrival will open a new...
Jim Wilson secures $100M for global approach aimed at reviving gene therapy field
A gene therapy pioneer thinks he has a solution to the field’s struggle to commercialize breakthrough cures: Go global. Jim Wilson’s Philadelphia-based company GemmaBio on Tuesday announced up to $100 million in funding to manufacture and test six gene therapies in...
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